1

ProbiFlora™ Adult Intensive Rescue Professional Information

2

ProbiFlora™ Adult Classic Bowel Support Professional Information

3

ProbiFlora™ Adult Everyday Flora Balance Professional Information

4

ProbiFlora™ Rx Professional Information

5

ProbiFlora™ Junior Everyday Flora Balance Professional Information

6

ProbiFlora™ Probiotic Infant Drops 3 strain-Regular drops Professional Information

7

Zeng MY, Inohara N and Nunez G.  Mechanisms of inflammation-driven bacterial dysbiosis in the gut. Mucosal Immunology 2017;10(10):18-26

8

Rinninella E., Raoul P, Cintoni M, et al. What is the Healthy Gut Microbiota Composition? A Changing Ecosystem across Age, Environment, Diet, and Diseases. Microorganisms 2019;7:1-22

9

Reference available on request

10

Reference available on request

11

IRI October 2021

12

DOH: MCC Complementary Medicines – Health Supplements Safety and Efficacy. 2016. Annexure C Allowable Levels and Claims for Probiotics

13

Adcock Ingram Data on File [Evidence-based Strains]

14

Wang, H., Wei, C-X., Min, L., et al. Good or bad: gut bacteria in human health and diseases. Biotechnology & Biotechnological equipment 2018;32(5):1075–1080.

15

Reference available on request

16

Wikipedia. Gastrointestinal tract. Available on: https://en.wikipedia.org/wiki/Gastrointestinal_tract. Accessed on: 22 August 2021

17

Gagliardi A, Totina V, Cacciotti F, et al. Rebuilding the Gut Microbiota Ecosystem. Int. J. Environ. Res. Public Health 2018;15(1679):1-24

18

Wikipedia. Flora (microbiology). Available on: https://en.wikipedia.org/wiki/Flora_(microbiology). Accessed on: 22 August 2021

19

Zhang Y-J, Li S, Gan, R-Y et al. Impacts of Gut Bacteria on Human Health and Diseases. Int J Mol Sci 2015;(16):7493-7519

20

World Gastroenterology Organisation Global Guidelines. Probiotics and Prebiotics. February 2017. Available on: https://www.worldgastroenterology.org/guidelines/global-guidelines/probiotics-and-prebiotics Accessed on: 22 August 2021

21

Schellack N and Combrinck Y. Prebiotics, probiotics and synbiotics: An update. S Afr Pharm J 2018;85(5):22-28

22

Weersma RK, Zhernakova A, and Fu J. Interaction between drugs and the gut microbiome. Gut 2020;69:1510-1519.

23

Lacy BE, Gabbard SL, and Crowell MD. Pathophysiology, Evaluation, and Treatment of Bloating: Hope, Hype, or Hot Air? Gastroenterology & Hepatology 2011;7(11):729-739.

24

HJ Wu and Wu E.  The role of gut microbiota in immune homeostasis and autoimmunity. Gut Microbes 2012; 3(1):4-14.

25

Neurohacker^® Collective. Adaes S. How The Gut Microbiota Influences Our Immune System. Available on: https://neurohacker.com/how-the-gut-microbiota-influences-our-immune-system Accessed on October 2021

26

Vighi G, Marcucci F, Sensi L, et al. Allergy and the gastrointestinal system. Clinical and Experimental Immunology 2008;153(Suppl. 1):3-6

27

ProbiFlora™ Junior Fit for School Professional Information

28

Tanaka M and Nakayama J. Development of the gut microbiota in infancy and its impact on health in later life. Allergology International 66 (2017) 515e522

29

Garaiova I, Muchová J, Nagyová Z, et al. Probiotics and vitamin C for the prevention of respiratory tract infections in children attending preschool: a randomised controlled pilot study. Eur J Clin Nutr 2015;69(3): 373-379.

1

Cleveland Clinic. (n.d.). Gut microbiome. [Online] October 2023. Available at: https://my.clevelandclinic.org/health/body/25201-gut-microbiome (Accessed: 26 February 2025).

2

Cleveland Clinic. (n.d.). The Gut-Brain Connection. [Online] September 2023. Available at: https://my.clevelandclinic.org/health/body/the-gut-brain-connection (Accessed: 4 November 2024).

3

Jäger, R., Mohr, A.E., Carpenter, K.C., et al. (2019) ‘International Society of Sports Nutrition Position Stand: Probiotics’, Journal of the International Society of Sports Nutrition, 16(1), p. 62. Available at: https://jissn.biomedcentral.com/articles/10.1186/s12970-019-0329-0 (Accessed: 26 February 2025).

4

Birmingham Gastroenterology Associates. (n.d.). Hydration and digestion: The link between water and gut health. Available at: https://bgapc.com/hydration-and-digestion-gut-health/ (Accessed: 28 February 2025).

5

Baranauskas, M. (2018) ‘Should you exercise if you are dehydrated?’, Healthfully, 28 November. Available at: https://healthfully.com/should-you-exercise-if-you-are-dehydrated-7838358.html (Accessed: 22 February 2025).

6

American Psychological Association. (2012) ‘That gut feeling’, Monitor on Psychology, 43(8). Available at: https://www.apa.org/monitor/2012/09/gut-feeling (Accessed: 26 February 2025).

7

Belkaid, Y. and Harrison, O.J. (2018). Homeostatic immunity and the microbiota. Frontiers in Immunology, 9, p.2398. Available at: https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2018.02398/full (Accessed 26 February 2025).