Gut development in kids

Development of the
paediatric gut microbiome

Kids gut health

What is GUT flora and
why should you care?

The human intestine harbours trillions of microbial cells8 which form a symbiotic (mutually beneficial) relationship with the host and play a vital role in both health and disease.35

These microbes, also known as microflora, play important roles in35:

  • Maintaining homeostasis
  • Providing essential nutrients
  • Dietary fibre metabolism
  • Proper development of the immune system
  • Early postnatal life development

Therefore, the gut microbiota is considered a
crucial factor for proper early life development
and lifelong health.35

GUT flora development during infancy,
childhood and adolescent

1

There is evidence that microbial colonisation of the infant gut may begin prior to birth as the presence of microbes have been found in the placenta, amniotic fluid and the umbilical cord.35

2

Research has found bacteria in the infant’s merconium (first baby stool), suggesting that colonisation may actually start before birth.35

3

During the first year of an infant’s life, the relatively simple neonatal microbiome matures and develops into a more complex microbiome, with more composition and functionality than expected at birth.36

4

While some studies have suggested that the paediatric microbiome reaches a relatively stable, adult-like configuration within the first 3 years of life, other studies have demonstrated continued development through childhood into the teenage years.37

Gut health in Children

What factors
influence the
development of
normal GUT flora?

In addition to potential in utero environmental influences, many factors have been found to contribute to early intestinal colonisation, such as35:

  •

    Gestational age at birth

  • Infant diet

  • Antibiotic treatment

  • Environment
1

Gestational age at birth

Studies have shown that the intestinal microbiota of preterm infants differs from that of healthy term infants. Prematurity is associated with a high risk for neonatal complications and can lead to significant disease and death rates. These premature neonates are often exposed to prolonged hospitalizations, antibiotics, and formula feeding which may all disrupt the maturation of health-associated microbial communities. Importantly, alterations in the microbiome of preterm infants have been correlated with increased risk for complications such as necrotising enterocolitis (NEC) and late-onset blood or systemic infection.35

2

Infant Diet

Breast-fed infants have microbiota enriched with beneficial flora such as Lactobacillus, Staphylococcus, and Bifidobacterium, as compared to formula-fed infants who have greater quantities of microbes associated with inflammation, with a more rapid maturation of their microbiome toward that of an adult-type composition.35

3

Antibiotic treatment

The use of antibiotic in early life has profound effects on the development of the gut microflora.35

4

Environment

Exposure to less sanitary environments including contact with household pets and siblings, may have a significant effect on the developing microbiome. The number of older siblings positively correlates with bacterial diversity and richness at 18 months of age.35

Gut health in children

What are potential
diseases associated with
GUT flora imbalance?

When the balance of the intestinal microbiota
becomes disrupted, alterations can lead to35:

  • Immunologic dysregulation (immune system dysfunction)
  • The development of diseases such as Clostridium difficile infection
  • Inflammatory bowel disease Irritable bowel syndrome (IBS)
  • Allergy and asthma
  • Obesity
  • Neurodevelopmental disorders such as autism

For more information refer to your healthcare provider.

* NEC – Necrotizing enterocolitis (NEC) is a medical condition where a portion of the bowel dies.

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